Clinical & Experimental Pathology
نویسنده
چکیده
In humans, HHcy causes various symptoms such as mental retardation, epilepsy, epileptic seizures and atherosclerosis, whose pathology is not fully understood. Pro-inflammatory mediators released by activated microglia secrete various neurotoxic factors such as NO and ROS, which contribute to neuronal degeneration in neurodegenerative diseases [1,2]. Within this context, HHcy proved to cause neuronal death, frequently associated with increased ROS levels [3]. Chronic treatment with Hcy induces oxidative stress in the rat brain by increasing lipid peroxidation and decreasing enzymatic and non-enzymatic antioxidant protection [4]. The reference range for mean plasma Hcy values in rats is situated between 10.4 ± 0.6 μM [5].
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